Title page for ETD etd-03022010-020016

Type of Document Master's Thesis
Author Flynn, Allison
URN etd-03022010-020016
Title Transition metals as anti-tumoral agents :some structure-function relationships of the platinum group metals
Degree Master of Science
Department Chemistry
Advisory Committee
Advisor Name Title
Merola, Joseph S. Committee Chair
Brewer, Karen J. Committee Member
Niehaus, Walter G. Jr. Committee Member
  • Antineoplastic agents
Date of Defense 1994-06-05
Availability restricted

Since the discovery that cis-diamminedichloroplatinum (II) possessed great antitumor properties, researchers have been synthesizing and screening metal coordination complexes for their potential anti-tumor activity. Hundreds of compounds have been tested, and few compounds possessed anti-tumor activity. This paper examines how the physical and chemical properties of complexes of the platinum group metals affect their toxicity and anti-tumor activity.

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