Title page for ETD etd-03122013-040148

Type of Document Master's Thesis
Author Smith, James Joseph
URN etd-03122013-040148
Title An investigation into hormonal regulation of ovine mammary gland growth during pregnancy
Degree Master of Science
Department Dairy Science
Advisory Committee
Advisor Name Title
Akers, Robert Michael Committee Chair
Beal, W. E. Committee Member
Gwazdauskas, Francis C. Committee Member
White, John M. Committee Member
  • Mammary glands
Date of Defense 1985-05-05
Availability restricted

Prepartum, multiparous ewes were randomly assigned to experimental groups and sacrificed at 50(n=5), SO(n=4),115(n=5), and 140(n=4) days of gestation. Serum harvested the week prior to slaughter was assayed for progesterone (PG), prolactin (PRL) and growth hormone (GH) concentrations. Mammary tissue obtained at slaughter was assayed for receptor concentrations of progesterone (PGr), prolactin (PRLr) and insulin (Ir). Quantitative biochemical, histological and autoradiographical analyses were used to measure mammary gland growth and indicated no significant glandular growth occurs prior to 8O days of gestation. However, a major phase of parenchymal growth occurred between 8O and 115 days which coincided with significant increases in PG, PGr and PRLr concentrations. Parenchymal growth continued further into late pregnancy. GH and Ir concentrations did not change significantly during pregnancy and were not strongly correlated to growth measurements. These results suggest that mammary gland growth is receptor-mediated and direct or indirect regulation of PGr and PRLr is primarily responsible for the observed growth phenomenon.

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