Title page for ETD etd-04142010-160829


Type of Document Dissertation
Author Parker, Jason Lloyd
Author's Email Address jasonparker@doctor.com
URN etd-04142010-160829
Title Natural Stressors, Posttraumatic Stress Disorder, and Wound Healing, in a Murine Model
Degree PhD
Department Psychology
Advisory Committee
Advisor Name Title
Harrison, David W. Committee Chair
Bell, Martha Ann Committee Member
Hoffman, Kurt A. Committee Member
Jones, Russell T. Committee Member
Keywords
  • Wound Healing
  • Awesomeness
  • Animal Models
  • Posttraumatic Stress
Date of Defense 2010-03-03
Availability unrestricted
Abstract
This study investigated the use of "naturalistic stressors" such as physical restraint and animal pheromones on the etiology of Posttraumatic Stress Disorder in a murine model. Pilot data suggest that stress effects may lead to an increase in the amount of time needed for cutaneous wounds to heal. Pilot data to support the creation of this model are presented suggesting that a delayed stress response may inhibit healing rates. In the present study an animal model of PTSD was used to investigate the effect of stress on the immune system. Yehuda and Antelman’s (1993) nonhuman animal model of Posttraumatic Stress Disorder was tested with respect to the animals’ immune response to cutaneous wounding. Additionally, effects of stress on exploratory behavior and activity were examined. The findings support the hypothesis that restraint and pheremonal stress and housing arrangements influence the ability of mice to heal a 1.5 mm punch biopsy, and exploratory behavior. The findings also support a profile for the Post-Traumatic Mouse.
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