Title page for ETD etd-05012010-174057


Type of Document Master's Thesis
Author Cameron, Kristin Nicole
URN etd-05012010-174057
Title The effects of illness on urinary catecholamines and their metabolites in dogs
Degree Master of Science
Department Veterinary Medical Sciences
Advisory Committee
Advisor Name Title
Monroe, William E. Committee Chair
Leib, Michael S. Committee Member
Meldrum, James Blair Committee Member
Panciera, David L. Committee Member
Keywords
  • pheochromocytoma
  • critical illness
  • norepinephrine
  • dog
  • metanephrine
  • catecholamines
  • normetanephrine
  • epinephrine
Date of Defense 2010-04-23
Availability unrestricted
Abstract
Background: Urinary catecholamines and metanephrines have been proposed as a diagnostic tool for identifying canine pheochromocytomas, but the effects of critical illness on urine concentrations of catecholamines and metanephrines is currently unknown.

Objectives: To examine the effects of illness on urine concentrations of catecholamines and metanephrines in dogs.

Animals: Twenty-five critically ill dogs and twenty-five healthy age- and gender-matched control dogs.

Methods: Prospective observational study. Urine was collected from healthy and critically ill dogs and urine concentrations of epinephrine, norepinephrine, metanephrine, and normetanephrine were measured by high-performance liquid chromatography (HPLC) with electrochemical detection. Urinary catecholamine and metanephrine:creatinine ratios were calculated and compared between groups.

Results: Urinary epinephrine, norepinephrine, metanephrine, and normetanephrine:creatinine ratios were higher in critically ill dogs when compared to a healthy control population (P = 0.0009, P < 0.0001, P < 0.0001, and P < 0.0001 respectively).

Conclusions and Clinical Relevance: Illness has a significant impact on urinary catecholamines and their metabolites in dogs. Further investigation of catecholamine and metanephrine concentrations in dogs with pheochromocytomas is warranted to fully evaluate this test as a diagnostic tool, however the findings of this study suggest that the results may be difficult to interpret in dogs with concurrent illness.

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