Title page for ETD etd-05102010-220058

Type of Document Master's Thesis
Author Davies, Sarah Elizabeth
Author's Email Address sdavies@vt.edu
URN etd-05102010-220058
Title Quantitative Pertechnetate Thyroid Scintigraphy and the Ultrasonographic Appearance of the Thyroid Gland in Clinically Normal Horses
Degree Master of Science
Department Biomedical and Veterinary Sciences
Advisory Committee
Advisor Name Title
Daniel, Gregory B. Committee Chair
Barber, Donald L. Committee Member
Crisman, Mark Virgil Committee Member
Larson, Martha Moon Committee Member
  • Thyroid
  • Horses
  • Ultrasound
  • Scintigraphy
  • Pertechnetate
Date of Defense 2010-04-28
Availability unrestricted
The purpose of this study was to report the scintigraphic and sonographic appearance of the thyroid gland in clinically normal horses so these modalities could be used to assess the thyroid gland in this species. Horses were divided into two age groups. Group A consisted of 8 horses between 3 and 10 years of age and Group B of 7 horses between 11 and 20 years of age. Total T4 concentrations were within the laboratory reference interval. Thyroid to salivary (T/S) ratio, percent dose uptake of pertechnetate and thyroid lobe volume were calculated. Echogenicity of thyroid lobes and presence of nodules were documented. The two groups were compared using appropriate parametric and nonparametic tests. Total T4 concentrations were significantly lower in the older group. Sixty minute mean ± standard deviation (SD) T/S ratios for older versus younger horses were 5.8 ± 3.0 and 5.3 ± 2.2, respectively. Sixty minute median and interquartile ranges for percent dose uptake of pertechnetate for older versus younger horses were 3.64% (1.5 to 3.98%) and 2.55% (2.33 to 2.90%), respectively. Mean ± SD thyroid lobe volumes for older versus younger horses were 18.93 ± 5.16 cm3 and 13.55 ± 3.56 cm3, respectively. Most thyroid lobes were hyper or isoechoic to the sternocephalicus muscle. Prevalence of thyroid nodules did not differ between groups. Older horses had trends for greater T/S ratios, percent dose uptakes and thyroid lobe volumes but had lower total T4 concentrations. Further studies using scintigraphy and ultrasound in horses with thyroid disease are planned.
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