Title page for ETD etd-051099-130149

Type of Document Master's Thesis
Author Wagner, Catherine Ann Robertson
Author's Email Address cwagner@vt.edu
URN etd-051099-130149
Title Reproduction and Enzyme Detoxification Activities in Mouse Lines Selected for Response to Fescue Toxicosis
Degree Master of Science
Department Animal and Poultry Sciences
Advisory Committee
Advisor Name Title
Hohenboken, William D. Committee Chair
Blodgett, Dennis J. Committee Member
Wong, Eric A. Committee Member
  • Mice
  • Festuca arundinacea
  • Reproductive Performance
  • UDP
  • Glutathione Transferase
Date of Defense 1999-04-15
Availability unrestricted


Catherine Ann Robertson Wagner

William D. Hohenboken, Chairman

Department of Animal and Poultry Sciences


In previous work, mouse lines were selected for resistance (R) or for susceptibility (S) to fescue toxicosis based upon reductions in post-weaning growth rate caused by an endophyte-infected diet. The first objective of the current experiment was to determine whether long term reproduction of S mice was more severely depressed than that of R mice by the toxic diet. The second objective was to quantify glutathione-S-epoxytransferase (GST) and uridine diphosphate glucuronosyl-transferase (UDPGT) activities in R and S dams form the experiment and to determine whether reproduction during continuous cohabitation and liver detoxification enzyme activities were correlated within line x diet groups. Effects of the toxic diet were detectable within the first litters produced. Reproduction was more seriously influenced by the toxic diet within the S line than within the R line when these measures were compared within four equal time phases. The effects of the toxic diet on reproduction were greatest early in the experiment; by the fourth time phase differences among line x diet groups, with the exception of litter weight, were not significant. Percentage differences in total reproduction were greater between S mice fed the non-toxic diet and S mice fed the toxic diet than those between the R mice fed the non-toxic and toxic diets. Averaged across diets, GST activities were higher in R mice, but UDPGT activities were not significant. Within R line mice, GST was correlated with three reproductive measures, but UDPGT activity was not correlated with reproduction within any line x diet group.

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