Title page for ETD etd-05142004-110908

Type of Document Master's Thesis
Author Smith, Sandra Kay
Author's Email Address sasmith1@vt.edu
URN etd-05142004-110908
Title Theoretical Feasibility Study of Preferential Hyperthermia Using Silicon Carbide Inserts
Degree Master of Science
Department Mechanical Engineering
Advisory Committee
Advisor Name Title
Scott, Elaine P. Committee Chair
Clark, David E. Committee Member
Thomas, James R. Jr. Committee Member
  • thermal dose
  • hyperthemia modeling
  • preferential hyperthermia
Date of Defense 2004-04-30
Availability unrestricted
Recently, hyperthermia has been investigated as an alternate therapy for the

treatment of tumors. The present project explored the feasibility of preferential

hyperthermia as a method of treating deep seated tumors. The overall goal of this

research was to determine theoretically if preferential heating could be used to attain the

desired thermal dose (DTD) for a two cm diameter tumor.

The simulations in this work show that, when using a single silicon carbide insert,

the model cannot provide enough energy for an entire 2 cm diameter tumor to receive the

DTD. However, when using an enhanced design model with multiple (4) silicon carbide

inserts, the DTD could be attained in a tumor up to 3.5 cm in diameter.

This study involved using the commercially available software package ANSYS

7.0 program to model a spherical 2 cm tumor, assuming the tumor is located in deep

tissue with a constant perfusion rate and no major blood vessels nearby. This tumor was

placed in the center of a cube of healthy tissue. To achieve the preferential heating of the

tumor, a silicon carbide insert was placed in the center of the tumor and microwave

energy was applied to the insert (in the form of volumetric heating). The thermal

modeling of this system was based on the Pennes Bioheat equation with a maximum

temperature limitation of 80 ºC. The Thermal Dose Analyzer software program was used

to evaluate the results of the thermal simulations (from ANSYS) to determine if the DTD

had been attained.

Additional enhanced design models were also examined. These models include 2

cm and 4 cm tumors with four silicon carbide inserts symmetrically placed about the

tumor and a 4 cm tumor model using a single silicon carbide insert with antennae

attached to the insert to increase energy distribution to the tumor. The simulations show

that only the enhanced design cases with four silicon carbide inserts can achieve the DTD

for an entire 2 cm tumor.

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