Title page for ETD etd-05192005-104254

Type of Document Dissertation
Author Shojania Feizabadi, Mitra
Author's Email Address mfeizaba@vt.edu
URN etd-05192005-104254
Title Physical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agents
Degree PhD
Department Physics
Advisory Committee
Advisor Name Title
Spillman, William B. Jr. Committee Chair
Indebetouw, Guy J. Committee Member
Mizutani, Tetsuro Committee Member
Ritter, Alfred L. Committee Member
Walker, Richard A. Committee Member
  • antimitotic drugs
  • dynamic instability
  • microtubule
Date of Defense 2005-04-29
Availability unrestricted
A mathematical approach to the concepts of copolymerization of microtubules in the presence of anti-mitotic drugs is presented in this work. A general feature of the mathematical equations is presented. The possibility of having analytical steady state solutions of dynamic equations is investigated. The structure of equations is narrowed down for the specific brand of anti-mitotic drug, colchicine. The behavior of total T-tubulin concentration in the steady state in a regeneration system is investigated and analyzed through the numerical calculations.
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