Title page for ETD etd-06032007-220948

Type of Document Master's Thesis
Author Atherton, Rachel Paget
Author's Email Address rachelatherton@hotmail.com
URN etd-06032007-220948
Title Efficacy of hyperimmunized plasma in the treatment of horses with acute diarrhea
Degree Master of Science
Department Biomedical and Veterinary Sciences
Advisory Committee
Advisor Name Title
Furr, Martin O. Committee Chair
Desrochers, Anne Committee Member
McKenzie, Harold C. III Committee Member
  • hyperimmunized
  • plasma
  • colitis
  • Horse
  • diarrhea
Date of Defense 2007-05-24
Availability unrestricted
The aim of this study was to evaluate the use of a hyperimmunized plasma containing high concentration of antibodies against Clostridium difficile, Clostridium perfringens and Salmonella sp in a referral population of equine colitis cases.

A prospective, blinded clinical trial was undertaken. Horses were enrolled if they were over 1 year old, duration of diarrhea at presentation was less than 72 hours, they had not received equine plasma within the last 3 months and the serum total protein was greater than 4mg/dl. Horses were randomized to receive hyperimmunized plasma, control plasma (collected from non-immunized horses) or no plasma therapy. Clinical parameters were recorded and a fecal score (2 -14) assigned (every 6 hours) based upon diarrhea frequency, volume and consistency, for a total of 72 hours. A score less than 5 was considered normal. Fecal consistency was observed until resolution, discharge or death. Complete blood counts and biochemical profiles were collected at admission, 24 and 72 hours and at admission, 24 hours and 48 hours respectively.

Forty two horses were enrolled and 38 horses completed the study. At study admission clinical and clinicopathological parameters, other than fecal frequency score were comparable between the groups. Fecal frequency score was significantly different between the treatment groups (p=0.003). The mean duration of diarrhea was 40.7±9.8 hours (mean ±SEM), 119.2±56.1 hours and 72.0±24.5 hours for the hyperimmunized plasma, normal plasma and control groups respectively. This data confirms the hyperimmunized plasma used in this study decreased the time to resolution of diarrhea.

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