Title page for ETD etd-06062008-163955

Type of Document Dissertation
Author Lanciotti, Robert Arthur
URN etd-06062008-163955
Title Baculovirus-directed expression of the phosphorylase kinase catalytic subunit :pseudosubstrate and calmodulin regulation
Degree PhD
Department Biochemistry and Anaerobic Microbiology
Advisory Committee
Advisor Name Title
Bender, Patrick K. Committee Chair
Bevan, David R. Committee Member
Kennelly, Peter J. Committee Member
Lederman, Muriel Committee Member
Potts, Malcolm Committee Member
  • Calmodulin
Date of Defense 1994-08-05
Availability restricted

Phosphorylase kinase (EC is a key enzyme involved in the regulation of the glycogenolysis pathway. It catalyzes the Ca2+ -dependent phosphorylation and activation of the enzyme glycogen phosphorylase to make the active form glycogen phosphorylase. Phosphorylase kinase is composed of 4 subunits with a stoichiometry of (αβγδ)4. The γ subunit is the catalytic subunit. The regulatory domain (residues 277-387) of γ contains a sequence resembling the sites phosphorylated in known γ substrates with the exception that a valine332 occurs at the analogous position of the phosphorylated serine or threonine residue.

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