Title page for ETD etd-06062008-164656

Type of Document Dissertation
Author Ferrante, Pamela L.
URN etd-06062008-164656
Title Acid-base regulation during exercise in the horse
Degree PhD
Department Animal Science
Advisory Committee
Advisor Name Title
Kronfeld, David S. Committee Chair
Herbein, Joseph H. Jr. Committee Member
Meacham, Thomas N. Committee Member
Rankin, Janet L. Walberg Committee Member
Williams, Jay H. Committee Member
  • Blood
Date of Defense 1994-01-15
Availability restricted

Effects of fat adaptation and NaHC03 supplementation on acid-base homeostasis were quantitated during repeated sprint exercise in horses. Contribution of strong ions ([SID]), Pco2, and weak electrolytes ([Atot]) to changes in plasma [H+] and the role of erythrocytes in acid-base balance were examined at rest and during exercise. Effects on plasma glucose and blood lactate [Lac-] concentrations due to sample handling were also assessed.

During exercise, blood [Lac-] was higher when horses received NaHC03 compared to water prior to exercise (P=0.0024), and in fat adapted horses compared to horses fed a control diet (P=O.0240). Blood [Lac-] was higher in fat adapted horses given NaHC03 compared to other diet/treatment combinations (P=O.0276). Plasma [SID] was higher during exercise when horses were given NaHC03 compared to plain water (P=O.0054), which contributed to decreasing [H+] and increasing [HC03-] during exercise (P=O.0001). Plasma Pco2 contributed less to increasing plasma [H+] during exercise in fat-adapted horses compared to horses fed the control diet (P=O.0282). Intraerythrocyte [SID] decreased (P=O.0160) and [Atod increased (P=O.0002) which contributed to increasing [H+] within the cell (P=O.0228).

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