Title page for ETD etd-06112000-02510045

Type of Document Master's Thesis
Author Du, Weiwei
Author's Email Address wdu@vt.edu
URN etd-06112000-02510045
Title Electrostatic Self-Assembly of Biocompatible Thin Films
Degree Master of Science
Department Materials Science and Engineering
Advisory Committee
Advisor Name Title
Claus, Richard O. Committee Chair
Hendricks, Robert W. Committee Member
Lu, Guo-Quan Committee Member
  • electrostatic self-assembly (ESA)
  • multilayer thin films
  • biocompatibility
  • protein adsorption
Date of Defense 2000-06-09
Availability unrestricted
The design of biocompatible synthetic surfaces is an important issue for medical applications. Surface modification techniques provide good approaches to control the interactions between living systems and implanted materials by modifying the surface characteristics.

This thesis work demonstrates the feasibility and effectiveness of the novel and low-cost electrostatic self-assembly (ESA) technique for the manufacturing of biocompatible thin film coatings. The ESA process is based on the alternating adsorption of molecular layers of oppositely charged polymers/nanoparticles, and can be applied in the fabrication of well-organized multilayer thin films possessing various biocompatible properties. ESA multilayer assemblies incorporating various biomaterials including metal oxides and polymers were fabricated, the uniformity, thickness, layer-by-layer linearity, and surface morphology of the films were characterized by UV/vis spectroscopy, ellipsometry, and AFM imaging.

Preliminary biocompatibility testing was conducted, concentrating on contact angle surface characterization and the in vitro measurements of protein adsorption. The use of Fourier Transform Infrared Reflection-Absorption Spectroscopy (FT-IRAS) for the investigation of the protein adsorption behavior upon the ESA multilayer films is presented.

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