Title page for ETD etd-07122000-16230006

Type of Document Master's Thesis
Author Pung, Thitiya
Author's Email Address tpung@vt.edu
URN etd-07122000-16230006
Title The Isolation of Natural Products From Plant Extracts
Degree Master of Science
Department Chemistry
Advisory Committee
Advisor Name Title
Kingston, David G. I. Committee Chair
Gandour, Richard D. Committee Member
Hanson, Brian E. Committee Member
Tanko, James M. Committee Member
  • oxoaporphine
  • verazines
  • natural product
  • biochanin A
  • DNA-damaging agents
Date of Defense 2000-06-28
Availability unrestricted
Bioassay-guided fractionation of the ethyl acetate extract of Virola sp.

(Myristicaceae) using the Sc7 yeast strain resulted in the isolation of the weakly cytotoxic

biochanin A (an isoflavone compound). The bioassay of three mutant yeast strains

(1138, 1104, and 1353) directed the isolation of DNA-damaging alkaloids from Solanum

hostmannii. These alkaloids were identified as verazine and (20R) epimer verazine. In

addition, three oxoaporphine alkaloids were isolated from the bark of Papualthia sp.

(Annonaceae). Oxocrebanine and atherospermidine showed DNA-damaging activity

whereas liriodenine had cytotoxic activity.

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