Title page for ETD etd-08092016-200555

Type of Document Master's Thesis
Author Pen, Olga Vladimirovna
Author's Email Address olgapen@vt.edu
URN etd-08092016-200555
Title “Calculation of the Effective Atomic Number for the Iodine Contrast Agent of the Varying Concentrations”
Degree Master of Science
Department Biomedical Engineering
Advisory Committee
Advisor Name Title
Guohua Cao Committee Chair
Daniel Bourland Committee Member
Stephen LaConte Committee Member
  • color CT
  • effective atomic number
  • iodine contrast agent
  • x-ray imaging
Date of Defense 2016-07-25
Availability unrestricted
The author discusses the difficulties that arise with the determination of the concentration of the iodinated contrast agents in the blood stream via the traditional gray-scale computer tomography and searches for the new imaging modalities that would provide for better sensitivity. The topic of the energy-discriminative color CT is discussed as a potential solution and its suitability is evaluated by performing the experiments on the contrast materials phantom and the phantom containing the iohexol solutions of varying concentrations on the original CT system assembled by the author. A method of the effective atomic number mapping is discussed as a viable alternative to the traditional attenuation-based tomography. The dependency of the effective atomic number of the compound on the energy of the x-ray beam is a phenomenon well recorded in the literature, yet no formal study exists to correctly predict the effective atomic number for a given compound. An extensive physical model is developed based on the previously presented models and adaptations unique to the task in order to determine the effective atomic numbers for exact energies experimentally. The method is tested on different materials. The resultant effective atomic numbers for the water, oil, and iohexol-water solutions of varying concentrations are presented in the study. The effects of the k-edge on both the linear attenuation curve and the effective atomic number curve are discussed. The possible future venues of the research are presented in the final part of the thesis.
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