Title page for ETD etd-11132011-231522

Type of Document Master's Thesis
Author Vereb, Heather A
URN etd-11132011-231522
Title Biomarkers of Lipid Oxidation in the Oral Cavity
Degree Master of Science
Department Environmental Sciences and Engineering
Advisory Committee
Advisor Name Title
Dietrich, Andrea M. Committee Chair
Agah, Masoud Committee Member
Vikesland, Peter J. Committee Member
  • lipid oxidation
  • breath analysis
  • micropreconcentrator
  • solid phase microextraction (SPME)
  • gas chromatography
Date of Defense 2011-10-14
Availability unrestricted
Measuring lipid oxidation is useful as a means of monitoring oxidative stress, such as that induced by clinical conditions or environmental exposure. Characteristic volatile compounds, often with low threshold odors, are secondary products of lipid oxidation reactions. Metallic flavor in food and beverages has been linked with oxidation of lipids in the oral cavity. Breath, an emerging medium for analysis of internal condition, is one means of measuring the metal-induced lipid oxidation responsible for this flavor. This project analyzes the breath of human subjects, as well as lipid oxidation of in vitro samples to identify compounds responsible for producing metallic flavor, which result from the oxidation of lipids in the oral cavity. Because these analytes are found at extremely low (picomolar to nanomolar) concentrations, preconcentration of samples prior to gas chromatography-mass spectrometry analysis is crucial. This study utilizes both solid phase microextraction (SPME) and micromachined silicon micropreconcentrators to concentrate compounds in breath to optimize analysis.
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