Title page for ETD etd-11152013-040545

Type of Document Dissertation
Author Cahilly, Glenn Moylan
URN etd-11152013-040545
Title The effect of thyroxine on protein biosysnthesis and ribonucleic acid metabolism in the rat
Degree PhD
Department Biochemistry and Nutrition
Advisory Committee
Advisor Name Title
Clemenbs J. Ackerman Committee Chair
Robert R. Schmidt Committee Member
Russell F. Miller Committee Member
  • Thyroid hormones
Date of Defense 1964-01-15
Availability restricted

Thyroxine was observed to stimulate the incorporation of radiolabeled amino acids into protein of cell-free Liver systems from treated normal and hypothyroid rats. However, the in vitro addition of the hormone only had a stimulatory effect, though quite erratic in magnitude, on the normal system. This difference in response has not been explained.

The hypothyroid rat was also characterized by lowered liver ribonucleic acid levels. It WEB found that thyroxine pretreatment resulted in increased ribonucleic acid levels only in the hypothyroid rat with the greater increase occurring in microsomal ribonucleic acid. No change was observed in the ribonucleic acid base ratios of the hypothyroid rat when compared to those of the normal. However, thyroxine pretreatment cf the hypothyroid rat did alter the rate of incorporation of radio phosphorus into the various nucleotides, although there was little difference in the total amount of incorporated label.

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