Title page for ETD etd-11292012-040248

Type of Document Dissertation
Author Dunnington, Elizabeth Ann
URN etd-11292012-040248
Title Selection for serum cholesterol, voluntary physical activity, 56- day body weight and feed intake in albino mice.
Degree PhD
Department Genetics
Advisory Committee
Advisor Name Title
White, John M. Committee Chair
Hinkelmann, Klaus H. Committee Member
Siegel, Paul B. Committee Member
Thye, Forrest W. Committee Member
Vinson, William E. Committee Member
  • Mice
Date of Defense 1978-01-15
Availability restricted

A short-term selection experiment was conducted with ICR albino mice produced by the reciprocal crossing of two lines of unselected animals which had been random—bred for 28 generations. Lines were developed by selecting for maximum and minimum serum cholesterol (SC) (lines CH and CL), voluntary physical activity (lines AH and AL), 56-day body weight (lines WH and WL) and feed intake (lines IH and IL). An unselected, random-bred control line was maintained with each pair of divergent selected lines (CC, AC, NC and IC, respectively). In the lines selected for SC, physical activity and 56-day body weight, selection was based on individual performance. Twenty-five paired matings plus five extra paired matings were used to perpetuate the lines each generation for five generations. The feed intake lines were perpetuated by within-sex, full-sib family selection with 30 paired matings per generation for five generations.

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