Title page for ETD etd-12152006-132023

Type of Document Master's Thesis
Author Chen, Shuo
Author's Email Address schen@vt.edu
URN etd-12152006-132023
Title The Application of the Expectation-Maximization Algorithm to the Identification of Biological Models
Degree Master of Science
Department Electrical and Computer Engineering
Advisory Committee
Advisor Name Title
Baumann, William T. Committee Chair
Wang, Joseph Committee Member
Xuan, Jianhua Jason Committee Member
  • Gene Regulatory Networks
  • EM Algorithm
Date of Defense 2006-12-11
Availability unrestricted
With the onset of large-scale gene expression profiling, many researchers have turned their attention toward biological process modeling and system identification. The abundance of data available, while inspiring, is also daunting to interpret. Following the initial work of Rangel et al., we propose a linear model for identifying the biological model behind the data and utilize a modification of the Expectation-Maximization algorithm for training it. With our model, we explore some commonly accepted assumptions concerning sampling, discretization, and state transformations. Also, we illuminate the model complexities and interpretation difficulties caused by unknown state transformations and propose some solutions for resolving these problems. Finally, we elucidate the advantages and limitations of our linear state-space model with simulated data from several nonlinear networks.
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