Title page for ETD etd-43098-1124

Type of Document Master's Thesis
Author Shifflett, D. Edward Jr.
Author's Email Address gfanconi@compuserve.com
URN etd-43098-1124
Title Physiological Responses in OSA Patients to Ramping Exercise After CPAP Treatment
Degree Master of Science
Department Human Nutrition, Foods, and Exercise
Advisory Committee
Advisor Name Title
Gregg, John M.
Ward, Christopher W.
Zedalis, Donald
Herbert, William G. Committee Chair
  • Obstructive sleep apnea
  • exercise
  • physiological repsonse
  • CPAP
Date of Defense 1998-04-24
Availability unrestricted

Continuous positive airway pressure (CPAP) is the primary

therapy administered for those afflicted with obstructive

sleep apnea (OSA). We examined the effects of CPAP therapy

on physiological variables during a ramped exercise. The

five male, OSA patients had mean values and standard

deviations for RDI=60.7 +/- 19.1, BMI=29.9 +/- 2.9, and

age=56 +/- 16.1 yr. Subjects were examined before and

after 4 wk of CPAP therapy. After 4 wk of CPAP therapy,

patient responses to exercise showed a 17.6%, (p<0.05)

improvement in rating of perceived exertion (RPE) at

identical power outputs (60% of the individual's apparent

functional capacity). Statistical significance was not

attained (p>0.05) upon analysis of the following parameters

at 60% of the individuals maximum workload although there

was a trend showing a decrease in these variables: heart

rate (6% improvement), VO2 (11.7% improvement) systolic

blood pressure (4% improvement), and rate pressure product

(8.6% improvement). This data shows that the decrease in

RPE during 60% of the individual's maximum predicted HR

reserve corresponded with an increase in sleep quality

(mean increase of 40%, 3.2 units) as measured by the

Pittsburgh Sleep Quality Index before and after 4 wk of

CPAP therapy. It was concluded that the improvement in

exercise tolerance could be attributed to the subjective

feelings of improved sleep quality after 4 wk of CPAP

therapy. Key Words: Obstructive sleep apnea---CPAP---

exercise---physiological responses.

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