Type of Document Dissertation Author Letsinger, William C. II URN etd-02132009-171953 Title Optimal one and two-stage designs for the logistic regression model Degree PhD Department Statistics Advisory Committee

Advisor Name Title No Advisors Found Keywords

- nonlinear logistic regression model
Date of Defense 1995-02-07 Availability restricted AbstractBinary reponse data is often modeled using the logistic regression model, a well known nonlinear model. Designing an optimal experiment for this nonlinear situation poses some problems not encountered with a linear model. The application of several optimality design criteria to the logistic regression model is explored, and many resulting optimal designs are given. The implementation of these optimal designs requires the parameters of the model to be known. However, the model parameters are not known. If they were, there would be no need to design an experiment. Consequently the parameters must be estimated prior to implementing a design.

Standard one-stage optimal designs are quite sensitive to parameter misspecification and are therefore unsatisfactory in practice. A two-stage Bayesian design procedure is developed which effectively deals with poor parameter knowledge while maintaining high efficiency. The first stage makes use of Bayesian design as well as Bayesian estimation in order to cope with parameter misspecification. Using the parameter estimates from the first stage, the second stage conditionally optimizes a chosen design optimality criterion. Asymptotically, the two-stage design procedure is considerably more efficient than the one-stage design when the parameters are misspecified and only slightly less efficient when the parameters are known. The superiority of the two-stage procedure over the one-stage is even more evident for small samples.

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