Type of Document Master's Thesis Author MacLean, Heidi Norma URN etd-03242004-165009 Title Plasma N-terminal Proatrial Natriuretic Peptide Concentration in Cats with Hypertrophic Cardiomyopathy Degree Master of Science Department Veterinary Medical Sciences Advisory Committee
Advisor Name Title Abbott, Jonathan A. Committee Chair Huckle, William R. Committee Member Pyle, Robert Lee Committee Member Keywords
- hypertrophic cardiomyopathy
- diastolic dysfunction
- atrial natriuretic peptide
Date of Defense 2004-03-12 Availability unrestricted AbstractPLASMA N-TERMINAL PROATRIAL NATRIURETIC PEPTIDE CONCENTRATION IN CATS WITH HYPERTROPHIC CARDIOMYOPATHY
Heidi N. MacLean
Jonathan A. Abbott, Chair
Objective: We sought to determine N-terminal proatrial natriuretic peptide concentrations [Nt-proANP] in plasma from cats with hypertrophic cardiomyopathy (HCM). Secondarily, we wished to evaluate the relationship between [Nt-proANP] and echocardiographic variables.
Methods: Venous blood samples were obtained from seventeen cats with HCM and from nineteen healthy cats. Plasma [Nt-proANP] was determined using an ELISA assay. The relationship between plasma [Nt-proANP] and M-mode, 2-dimensional and Doppler echocardiographic variables was evaluated. Cats that were hyperthyroid or had evidence of renal disease were excluded from the study.
Results: The mean plasma [Nt-proANP] was higher in cats with HCM (3.81 +/- 1.23 pmol/l) than in control cats (3.08 +/- 1.41 pmol/l); however, this difference was not statistically significant (p=0.17). There was a significant correlation between plasma [Nt-proANP] and left ventricular posterior wall thickness (r = 0.42; p=0.01). Additionally, plasma [Nt-proANP] was correlated with left atrial size (r = 0.35; p=0.03). A linear regression model was developed to further explore these relationships. LAs2D and LVPWd had an interactive effect on plasma [Nt-proANP] (R2 = 0.2737; p= 0.02). There was no correlation between any other echocardiographic variable and plasma [Nt-proANP]. There was no correlation between plasma [Nt-proANP] and heart rate (HR), body-weight, or age.
Conclusions: Cats with HCM do not have significantly higher plasma [Nt-proANP] than normal cats. There was a significant linear relationship between [Nt-proANP] and LAs2D, LVPWd and the model that described their interaction.
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