Type of Document Master's Thesis Author King, Michael David URN etd-05162006-083521 Title The Effect of Nephrotomy on Renal Function and Morphology in Normal Cats Degree Master of Science Department Biomedical and Veterinary Sciences Advisory Committee
Advisor Name Title Waldron, Don R. Committee Chair Barber, Donald L. Committee Member Larson, Martha Moon Committee Member Saunders, Geoffrey K. Committee Member Troy, Gregory C. Committee Member Keywords
- Urogenital Surgery
Date of Defense 2006-05-02 Availability restricted AbstractObjective:
To assess effects of bisection nephrotomy on renal function, size, and morphology in cats over a period of 12 weeks.
Controlled, randomized, blinded experiment.
Ten adult female cats.
Glomerular filtration rate (GFR), as determined by quantitative renal scintigraphy using 99mTc-DTPA, urinalysis, urine culture, and sonographic measurement of renal size were performed pre-operatively. A left or right nephrotomy (five randomly assigned cats in each group) was performed. Total and individual kidney GFRs were determined in each cat 2, 28 and 84 days post-operatively. Both kidneys were measured sonographically 28 and 86 days postoperatively and an ultrasound-guided biopsy of each kidney was obtained 86 days postoperatively.
No significant differences in mean GFR and kidney size of the operated versus un-operated kidneys were observed at any time period. Individual GFR and renal size of all except one of the cats remained within normal limits. Two additional cats had evidence of transient ureteral obstruction in the immediate post-operative period. No significant histologic abnormalities were observed in any biopsy.
Bisection nephrotomy in normal cats did not adversely affect renal function or morphology over the three month post-operative period.
Bisection nephrotomy can be safely performed in normal feline kidneys without causing a significant deleterious effect on renal function. Studies in animals with pre-existing renal insufficiency are needed to insure no adverse effects would occur in clinical cases where this surgical procedure is warranted.
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