Type of Document Master's Thesis Author Pung, Thitiya Author's Email Address firstname.lastname@example.org URN etd-07122000-16230006 Title The Isolation of Natural Products From Plant Extracts Degree Master of Science Department Chemistry Advisory Committee
Advisor Name Title Kingston, David G. I. Committee Chair Gandour, Richard D. Committee Member Hanson, Brian E. Committee Member Tanko, James M. Committee Member Keywords
- natural product
- biochanin A
- DNA-damaging agents
Date of Defense 2000-06-28 Availability unrestricted AbstractBioassay-guided fractionation of the ethyl acetate extract of Virola sp.
(Myristicaceae) using the Sc7 yeast strain resulted in the isolation of the weakly cytotoxic
biochanin A (an isoflavone compound). The bioassay of three mutant yeast strains
(1138, 1104, and 1353) directed the isolation of DNA-damaging alkaloids from Solanum
hostmannii. These alkaloids were identified as verazine and (20R) epimer verazine. In
addition, three oxoaporphine alkaloids were isolated from the bark of Papualthia sp.
(Annonaceae). Oxocrebanine and atherospermidine showed DNA-damaging activity
whereas liriodenine had cytotoxic activity.
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