Title page for ETD etd-09052008-130704

Type of Document Master's Thesis
Author Zhang, Lin
URN etd-09052008-130704
Title The involvement of IRAK-1 in the regulation of NFATc2 in T cells
Degree Master of Science
Department Biology
Advisory Committee
Advisor Name Title
Li, Liwu Committee Chair
Gogal, Robert M. Jr. Committee Member
Good, Deborah Jean Committee Member
Melville, Stephen B. Committee Member
  • NFATc2
  • adaptive immunity
  • IRAK-1
  • Foxp3
  • signal transduction
Date of Defense 2008-08-29
Availability unrestricted
Interleukin-1 receptor associated kinase -1 is a protein kinase pivotal in mediating signals for innate immune responses. Here, I report that IRAK-1 also regulates cell-mediated immune responses. NFATc2 (nuclear factor of activated T cells) was found to be associated with IRAK-1 in T cells in vitro and its activity was elevated in the absence of IRAK-1. In addition, IRAK-1-/- mice had increased naturally occurring regulatory T cells and inducible regulatory T cells as well as Th1 responses as compared to WT mice. The findings suggest that activated T cells might employ IRAK-1 to mediate the regulation of acquired immunity. Therefore, IRAK-1 may participate in direct signaling cross talk between the innate and the acquired immunity.
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