Type of Document Master's Thesis Author Cadorette, Veronica R. URN etd-09082012-040648 Title Chemical investigation of Dicranum fulvum for anticancer activity Degree Master of Science Department Chemistry Advisory Committee
Advisor Name Title Kingston, David G. I. Committee Chair Bell, Harold M. Committee Member Taylor, Larry T. Committee Member Keywords
Date of Defense 1989-08-15 Availability restricted Abstract
Biological screening of extracts of various bryophytes showed that the species Dicranum fulvum gave extracts with activity in both in vitro and in vivo bioassays. This plant was thus selected for extraction and fractionation, monitored by iin vitro bioassays.
Isolation was guided by a combination of bioassay and chemical methods, and led to the isolation of three compounds, betulin, 9,l9- cyclolanost—23—ene—3,25—diol, and B-sitosterol. Purification was achieved by open column, flash column, gel filtration, thin layer chromatography, the chromatotron and crystallization.
The isolated compounds were identified by comparisons of spectroscopic data with those of authentic samples and the matching of experimental and literature melting points and optical rotations.
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