Title page for ETD etd-11292012-040248
|Type of Document
||Dunnington, Elizabeth Ann
||Selection for serum cholesterol, voluntary physical activity, 56- day body weight and feed intake in albino mice.
|White, John M.
|Hinkelmann, Klaus H.
|Siegel, Paul B.
|Thye, Forrest W.
|Vinson, William E.
|Date of Defense
A short-term selection experiment was conducted with ICR albino
mice produced by the reciprocal crossing of two lines of unselected
animals which had been random—bred for 28 generations. Lines were developed
by selecting for maximum and minimum serum cholesterol (SC)
(lines CH and CL), voluntary physical activity (lines AH and AL), 56-day body weight (lines WH and WL) and feed intake (lines IH and IL).
An unselected, random-bred control line was maintained with each pair
of divergent selected lines (CC, AC, NC and IC, respectively). In the
lines selected for SC, physical activity and 56-day body weight, selection
was based on individual performance. Twenty-five paired matings
plus five extra paired matings were used to perpetuate the lines each
generation for five generations. The feed intake lines were perpetuated
by within-sex, full-sib family selection with 30 paired matings per
generation for five generations.
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