Type of Document Master's Thesis Author Robinson, Paul S. Author's Email Address email@example.com URN etd-22398-215911 Title Development of Methodologies for the Noninvasive Estimation of Blood Perfusion Degree Master of Science Department Mechanical Engineering Advisory Committee
Advisor Name Title Diller, Thomas E. Committee Chair Diller, Thomas E. Committee Member Scott, Elaine P. Committee Member Veit, Hugo P. Committee Member Keywords
- blood perfusion
- biothermal modeling
- biothermal heat transfer
- parameter estimation
- heat flux sensors
Date of Defense 1998-01-29 Availability restricted AbstractThis work focuses on the development of a system to
noninvasively estimate blood perfusion using thermal methods. This is
accomplished by the combination of a bioprobe, biothermal model, and
parameter estimation techniques. The probe consists of a heat flux
sensor and surface thermocouple placed in contact with tissue
while the opposite side is cooled by jets of room temperature air. The
biothermal model predicts the temperature and heat flux within tissue
and probe based upon the input of blood perfusion and the thermal contact
resistance between probe and tissue. Parameter estimation techniques
are developed that use the model to simultaneously estimate blood
perfusion and contact resistance based on experimental heat flux
and/or temperature. A gradient based system minimizes a sum of
squares error function based on either or both heat flux and
temperature. This system
is tested on human forearms and in controlled flow rate experiments
using tissue phantoms. Blood perfusion estimates from the controlled
experiments are positively correlated with experimental flow rate.
Experimental measurements and statistical analysis show distinct
variations in the heat flux signal and rises in perfusion estimates
with increasing flow rate. This research validates the use of
thermal and parameter estimation methods to develop a practical,
noninvasive probe to clinically measure blood perfusion.
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