Type of Document Master's Thesis Author Baloglu, Erkan Jr. Author's Email Address firstname.lastname@example.org URN etd-72498-21309 Title A New Synthesis of Taxol®, from Baccatin III Degree Master of Science Department Chemistry Advisory Committee
Advisor Name Title Kingston, David G. I. Committee Chair Calter, Michael A. Committee Member Deck, Paul A. Committee Member Keywords
- anticancer drugs
Date of Defense 1998-08-07 Availability unrestricted AbstractTaxol®,, an important anticancer drug, was first isolated in extremely low yield
from the bark of the western yew, Taxus brevifolia. The clinical utility of Taxol has
prompted a tremendous effort to obtain this complex molecule synthetically. Due to the
chemical complexity of Taxol, its commercial production by total synthesis is not likely to
Another natural product, 10-deacetyl baccatin III, is readily available in higher
yield. Several methods have been reported for the synthesis of Taxol by coupling baccatin
III and the N-benzoyl-b-phenylisoserine side chain. A new method for the synthesis of
Taxol from baccatin III is reported, and this method is compared with other methods.
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